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Faecalibacterium Prausnitzii: The Gut Microbe That Prevents Inflammation

Faecalibacterium Prausnitzii: The Gut Microbe That Prevents Inflammation

Faecalibacterium prausnitzii is a beneficial microbe that resides in the human colon. This butyrate-producing bacterium has anti-inflammatory properties that promote gut health.

The human gut is home to trillions of bacterial cells, collectively known as the microbiome or microbiota. Faecalibacterium prausnitzii is a common resident that scientists have pegged as a candidate for next-generation probiotics.

☝️DISCLAIMER☝This article is for informational purposes only. It is not intended to constitute or be a substitute for professional medical advice, diagnosis, or treatment.


Table of contents


What is Faecalibacterium prausnitzii?

Faecalibacterium prausnitzii (also known as F. prausnitzii) constitutes 5–15% of the human gut microbiome, making this microbe an important contributor to balance and digestive health. It is a species of bacteria that belongs to the Firmicutes phylum – a classification of bacteria.

Faecalibacterium prausnitzii taxonomy by Atlas Biomed

Several species of Firmicutes, including F. prausnitzii, produce butyrate, a critical short-chain fatty acid for gut health.

F. prausnitzii is currently the only known species of the Faecalibacterium genus. Even though microbiome analyses have revealed that these bacteria are very common, scientists still have limited information about them.

When analysing bacteria, researchers prefer to grow microbes to evaluate their functions. Unfortunately, Faecalibacterium prausnitzii is a strictly anaerobic microorganism, meaning it can’t survive exposure to oxygen, which complicates the research process.

16S rRNA sequencing used for microbiome testing, including the Atlas Microbiome Test, has made it possible to analyse the composition of the microbiota, including the abundance of F. prausnitzii. Another technique, known as shotgun sequencing, helps identify the genetic make-up of gut bacteria and identify what functions they perform.

Faecalibacterium-search-terms

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Recent studies have revealed that there is, in fact, great diversity of genetic profiles and functions between microbes that are classified as Faecalibacterium prausnitzii. It is likely that, in coming years, several species and strains related to F. prausnitzii will emerge and refine our knowledge of this microorganism.

Health functions of Faecalibacterium prausnitzii

Faecalibacterium prausnitzii produces butyrate, an essential short-chain fatty acid that supports a healthy intestinal environment. In addition, this microbe has several other anti-inflammatory and metabolic functions that make it an important participant in human health.

Function Why it’s important
Butyrate synthesis Butyrate is the primary fuel for the cells of the gut lining. It has anti-inflammatory properties and stimulates the body’s production of glutathione, an antioxidant molecule.
Enzyme production F. prausnitzii produces a range of enzymes that enable it to break down complex sugar molecules and use them for fuel in other metabolic functions.
Immune modulation Strains of F. prausnitzii can prevent inflammation and moderate the immune cells by acting on T cells and cytokines (Il-8, IL-10, IL-12) and producing anti-inflammatory molecules.

Anti-inflammatory functions

70% of the body’s immune tissues are located in the intestines. Known as gut-associated lymphoid tissue (GALT), this tissue provides essential protection against pathogens and damage inside the body, which can result in inflammation.

A balanced gut microbiome contains bacteria, like Faecalibacterium prausnitzii, that have learned to work in tandem with the immune system to prevent inflammation and protect against opportunistic bacteria that can cause infections.

Anti-inflammatory functions of Faecalibacterium prausnitzii.

Butyrate maintains the integrity of the gut lining, which prevents pathogens from entering the body via the gut. It stimulates the growth of villi (microscopic extrusions on the gut barrier) and encourages the production of mucin, a protective gel that coats the gut lining.

The intestinal barrier depends on T-junction proteins to prevent the contents of the gut from leaking into the bloodstream. Butyrate encourages tightly-knit T-junction proteins by activating AMP-activated protein kinase (AMPK), a protein that encourages T-junction assembly.

Faecalibacterium prausnitzii supernatant (liquid extracted during lab studies) have been shown to suppress the production of pro-inflammatory IL-8 immune proteins. F. prausnitzii also helps combat inflammation by activating T cells that produce IL-10, an anti-inflammatory protein.

These microbes can produce shikimic, an acid commonly found in plants that is able to protect against inflammation induced by lipo- polysaccharides (LPS). LPS are toxins on the external membrane of some bacteria that can activate the immune system and cause inflammation.

F. prausnitzii can also make salicylic acids, which help prevent bacteria from creating biofilms, a common trait of some infection-causing microbes.

Faecalibacterium prausnitzii and digestive diseases

The abundance of F. prausnitzii in a person’s microbiome is influenced by their health status and colonic environment. This is particularly relevant because below-average levels of F. prausnitzii have been found in patients with digestive diseases.

Crohn’s disease and ulcerative colitis

Research indicates that a healthy gut pH (5.7–6.7) provides optimal conditions for F. prausnitzii growth, while a highly acidic environment suppresses the growth of Faecalibacterium prausnitzii. In particular, people with ulcerative colitis and Crohn’s disease tend to have acidic stools, which may help explain why their microbiomes lack F. prausnitzii.

Difference between Crohn's disease and ulcerative colitis by Atlas Biomed.

The presence of slightly elevated levels of bile and its components can also affect F. prausnitzii abundance. Bile is a substance secreted by the liver to break down fats during digestion. Bile salts have been shown to inhibit Faecalibacterium prausnitzii.

Researchers hypothesise that this sensitivity to bile could explain why these microbes are less abundant in patients with Crohn’s disease. People with this type of inflammatory disease tend to have higher levels of bilirubin, the pigment that gives bile its colour, especially if they have had part of their bowel removed.

Colorectal cancer

The anti-inflammatory functions of butyrate include anti-cancer properties. This short-chain fatty acid is a histone deacetylase (HDAC) inhibitor: it suppresses the activity and life cycle of cancer cells. This has led researchers to investigate the role of Faecalibacterium prausnitzii in colorectal cancer.

Atlas Microbiome Test for Faecalibacterium prausnitzii

Patients with colorectal cancer have less butyrate-producing bacteria, including Faecalibacterium prausnitzii. It has been suggested that, as a consequence of lower butyrate production, the cells of the gut lining may be more susceptible to damage, which could increase the risk of developing cancer.

Diabetes

Diabetes is a metabolic disease in which the body loses the ability to control blood sugar due to impaired insulin function. Elevated circulating glucose damages the blood vessels and increases the risk of heart disease.

A number of studies in humans have identified imbalances in the gut microbiome (dysbiosis), which weaken the gut lining and allow undesirable particles into the body that can disrupt other organs. Scientists believe that dysbiosis precedes and contributes to the development of diabetes.

Diabetes patients have lower levels of Firmicutes, including Faecalibacterium prausnitzii and other butyrate-producing bacteria that fortify the gut lining.

Studies show that lipopolysaccharides, pro-inflammatory molecules found on some gram-negative bacteria, can enter the bloodstream when the gut barrier is weak and impair B-cell function in the pancreas – the cells that produce insulin.

Do you have enough Faecalibacterium prausnitzii?

You can check the abundance of Faecalibacterium prausnitzii and see whether your gut bacteria makes enough butyrate with the Atlas Microbiome Test. Plus, you’ll receive tailored food recommendations to boost your microbiome and support gut health.

Leigh Stewart
Leigh Stewart Head of Atlas Biomed content, trained chef and avid fermenter of edible bacteria.

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