The Facts On Taking Probiotics With Antibiotics, And Antibiotics With Food

The Facts On Taking Probiotics With Antibiotics, And Antibiotics With Food

Most people will be prescribed antibiotics for a bacterial infection at some point, but they can seriously affect your gut. The good news is that there are things you can do to keep your microbiome flourishing.

Antibiotics treat bacterial infections, but they often cause side effects, especially for your gut and its resident ecosystem of bacteria. Some foods can help to manage the fallout, while others might make them worse. So knowing what foods to eat when taking antibiotics is helpful.

The ecosystem of beneficial and harmless bacterial cells in your colon is called a gut microbiome, and it's essential for your whole body. However, antibiotics do not distinguish between good and bad bacteria, and this can have long-term consequences for the health of your microbiome.


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When a bacterial infection takes hold, antibiotics may be the only line of defence, but they come with side effects like an upset stomach after antibiotics and diarrhoea. They also put women at risk of getting vaginal yeast infections.

However, antibiotics are poorly understood by the general public, so let’s look at the benefits of antibiotics probiotics taken together and how to restore gut flora after antibiotics.

What’s an antibiotic?

Antibiotics are an important tool against bacterial infections. Depending on what class of antibiotic it is, this medication will stop the infection from spreading by one of two ways: killing bacteria, or by preventing them from reproducing.

Taking antibiotics without food can hurt your stomach by Stephen Foster.
Taking antibiotics without food can hurt your stomach and your gut

Some are broad-spectrum (to be used when the cause of the infection is unclear, or there is no targeted treatment for that bacterium), but that means they attack many kinds of bacteria, including the beneficial ones that help keep your gut healthy. Others are specialised: they target specific bacteria.

Antibiotics are usually prescribed to help fight infections caused by pathogenic bacteria. They don’t work against viruses or fungi, which is why they can only be prescribed by doctors and should only be used when absolutely necessary.

Antibiotic risks for your microbiome

Antibiotics can’t tell the difference between the healthy bacteria your body needs and the bad bacteria causing an infection. In fact, the consequences for your microbiome may still be visible after six months. Sometimes, they can even be permanent. We recommend checking your microbiome status three months after taking antibiotics.

That’s because your gut microbiome is critical for your health. It's involved in immune system function, body weight, and even brain health. However, antibiotics can lower the diversity of microbes present in your gut, causing imbalances that increase the risk of inflammation and lower your protection from diseases.

The use of antibiotics during pregnancy, in newborns and infants, is especially problematic because the gut microbiome develops in early life and, during that period, it educates the immune system.

Infants who are exposed to antibiotics either before or after birth have been shown to have fewer health-promoting microbes like Bifidobacteria and Lactobacillus that are dominant members of the infant microbiome.

The link between antibiotics and weight gain starts in childhood by Henley Design Studio.
The link between antibiotics and weight gain starts in childhood

Research shows that antibiotic disruption of the gut microbiome at a young age is linked with an increased risk of allergies, asthma, and autoimmune disorders. Antibiotics and weight gain are also a major issue: this medication has been pinpointed as an important factor in the obesity epidemic.

Since the introduction of antibiotics into clinical medicine, their use has increased, alongside the prevalence of obesity. Antibiotic resistance has also increased, and this is bad because infections become harder to treat and that makes them more dangerous to humans.

For example, Clostridium difficile is a deadly bacterial infection affecting the colon that is common in healthcare settings, and it's resistant to most antibiotics. Nowadays, doctors have found that transplanting a healthy microbiome into patients is most effective when treating for C. diff.

☝️Can antibiotics cause weight gain? Yes, there is plenty of evidence to suggest that antibiotics cause weight gain.

Why should you take probiotics with antibiotics?

Antibiotics are important for treating bacterial infections, but they’re not gut-friendly. Fortunately, you can take steps to preserve and restore your microbiome for whole body health during and after a course of antibiotics.

Probiotics help to keep (or restore) order in your gut by adding beneficial bacteria which balance the bacterial communities in your gut microbiome. They include foods and supplements which contain a live bacterium with health benefits for humans.

Research shows that probiotics and antibiotics taken together can reduce the risk of side effects, like diarrhoea. They even help to restore some of the healthy gut microbes lost through antibiotic therapy. Strains of Lactobacillus and Saccharomyces (a beneficial yeast) can help mitigate antibiotic side effects.

TIP Find out how your gut microbiome responds to prebiotics and probiotics with the Atlas Microbiome Test.

Taking probiotics with antibiotics

Many people experience nausea, diarrhoea, tummy upsets, bloating, and even vomiting when taking antibiotics. Some doctors recommend taking a probiotic supplement at the same time to help with these digestive side effects.

Yogurt and antibiotics are a suitable combination by Wesual Click.
Yogurt and antibiotics are a suitable combination

Even after taking antibiotics, you can boost your own beneficial bacteria with probiotic foods and supplements. They contain microbes that maintain your gut environment and help regulate your microbiome, keeping opportunistic pathogens at bay and beneficial ones thriving.


Probiotics for antibiotics

Probiotic bacteria Probiotic and fermented foods Prebiotics
Bifidobacteria Yoghurt, milk kefir Wholegrains, onions, berries, apples
Lactic acid bacteria (e.g. lactobacillus and lactococcus) Yoghurt, Lacto-fermented vegetables, sauerkraut Soy, barley, apples, chicory root

All bacteria need to eat. Like other beneficial bacteria, probiotic microbes enjoy plant-based foods rich in prebiotic fibre (a fancy word to describe food in your diet that nourishes your gut microbiota).

Fermented foods are of particular interest to scientists at the moment because they contain known probiotic bacteria as well as prebiotics that keep the probiotic bacteria nourished.

Can I take probiotics with antibiotics? Take antibiotics and probiotics a few hours apart so you don’t expose healthy bacteria to this medication.

How to replenish good bacteria after antibiotics

Restoring gut flora after antibiotics is achievable if you eat the correct foods: plants. That's because your gut microbes turn fibers and plant nutrients into important metabolites like short-chain fatty acids (SCFAs) - acetate, butyrate, and propionate - which have important functions:

  • fuelling the cells of your gut lining
  • preventing damage to your cells (antioxidant)
  • anti-cancer properties
  • regulating your appetite
  • lowering cholesterol
  • combating inflammation
  • maintaining gut pH
  • nourishing other beneficial bacteria
  • deterring opportunistic microbes
By eating plant-based foods in a wide range of colours and textures, you will help to keep your fibre intake up while encouraging microbiome diversity. Plus, plant foods are also packed with antioxidant polyphenols that nourish gut microbes and help prevent damage to your body's cells.

When to take antibiotics before or after food?

When you are given them, it usually clearly states whether you need to take antibiotics with food. Taking them correctly is key to their effectiveness. You should take them with water because this doesn’t interfere with their effectiveness as some fruit juices do.

Avoid grapefruit right after antibiotics by Rayia Soderberg.
Avoid grapefruit right after antibiotics

Some types will need to be taken with food to reduce the risk of side effects like nausea and vomiting. After all, antibiotics are potent medicines, so it’s not really surprising that they can irritate your digestive system too.

☝️If you’re going to take probiotics with antibiotics, it is best to take them a few hours apart so this medication doesn't affect the probiotic bacteria too.

Taking antibiotics with food

Some foods and drinks can interfere with the effectiveness of antibiotics or make their side effects worse. Knowing what to avoid is essential. For example, grapefruit shouldn’t be eaten with many types of prescription medications, including antibiotics.


What to avoid

  • grapefruit and its juice
  • calcium-fortified foods
  • alcoholic beverages

That’s because grapefruit can interfere with the enzymes responsible for breaking down antibiotics, making them less effective while increasing the probability of side effects. Other studies have shown that foods fortified with calcium may affect the absorption of some antibiotics and make them less effective.

Alcohol is a beverage that you really must avoid when on antibiotics. Depending on the type of antibiotic, there are three potential risks. Some increase the absorption of alcohol, resulting in a stronger state of inebriation.

In other cases, when antibiotics interact with alcohol, they can increase the risk of side effects like nausea, vomiting, and drowsiness. In extreme cases, consuming alcohol and antibiotics can cause liver damage.

☝️Should you take antibiotics with food? Read your prescription, consume with food when indicated and avoid any foods specified.

Probiotics–antibiotics: the bottom line

Antibiotics are important against bacterial infections, but they can cause side effects, including long-term negative changes in the composition of your gut microbiome because they do not distinguish between health-promoting microbes and the ones causing illness.

Learn how to listen to your gut with Atlas Biomed
Learn how to listen to your gut with AtlasBiomed

Taking a probiotic supplement or eating probiotic foods may help mitigate immediate side effects, like diarrhoea, and they can help to get your gut microbiome back on track afterwards too.

Incorporating foods that are rich in fibre, as well as fermented foods containing live bacterial cultures, can enrich your microbiome with health-promoting bacteria that help restore this ecosystem to its former glory.

It’s also good to know which foods and beverages to avoid when taking a course of antibiotics. Stay away from alcohol, grapefruit, and calcium-fortified foods to avoid any unnecessary harm from this medication.

You can check in on your gut microbes three months after taking antibiotics with the Atlas Microbiome Test. You'll also receive personalised food recommendations to restore microbiome balance with your diet.

Sources:
Leanne Edermaniger
Leanne Edermaniger Science writer who enjoys laughing which is scientifically proven to help you live longer.

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